Introduction: Neonatal hyperbilirubinemia is a widespread and significant clinical problem among neonates worldwide. Globally, every year about 1.1 million babies develop it and the vast majority resides in developing countries like Ethiopia. It is a major cause of hospital neonatal intensive care unit admission and readmissions during the neonatal period. As far as our knowledge is concerned there is no such study conducted in St. peter specialized hospital so far. Hence the objective of this study is to determine Prevalence and associated factors of hyperbilirubinemia among neonates admitted to neonatal intensive care unit of Saint Peter Specialized Hospital, Addis Ababa, Ethiopia from January, 1/2022 to January 1, 2023. Methods: A Facility based Retrospective cross sectional study was conducted among one hundred forty two (142) neonates admitted at St. peter specialized hospital by using systematic random sampling technique. Data on socio-demographic characteristics and, potential associated factors for hyperbilirubinemia were collected by a structured data extraction checklist. For this study, a total serum bilirubin level ≥5 mg/dL was taken as the cutoff point to diagnose hyperbilirubinemia. Data entry was done by EPI info version 7, and analyzed using SPSS version 23.0. Binary logistic and multiple variable logistic regression models were used to identify associated factors. Association between were considered statistically significant only if A two-sided P-value <0.05 at 95% confidence level. Result: A total of 142 neonates were included in the study making response rate 100%. The overall prevalence of neonatal hyperbilirubinemia was 35 (24.6 %) with (95% CI: 17.6-31.7). Among several possible factors: Being male sex [AOR]:7.7, 95%CI (1.88, 32.1)], Birth trauma [AOR]: 17, 95%CI (3.8, 76.6), neonatal sepsis [AOR]: 10.9, 95%CI (2.9, 41.79)] and ABO incompatibility [AOR]: 22, 95%CI (4.7, 102.05)] were independent determinants of neonatal hyperbilirubinemia. Conclusion and recommendation: The prevalence of Neonatal Hyperbilirubinemia was quite high. Among identified associated factors for hyperbilirubinemia in this study: neonatal sex, Birth trauma, Sepsis and ABO incompatibility were the leading cause. Hence Health care provider working at NICU should undergo routine screening and investigations for TSB are imperative for early detection and timely intervention.
| Published in | Science Journal of Public Health (Volume 11, Issue 3) |
| DOI | 10.11648/j.sjph.20231103.12 |
| Page(s) | 56-63 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Neonatal, Hyperbilirubinemia, St. Peter Specialized Hospital
| [1] | F. Melinda, I. W. B. Suryawan, and A. A. M. Sucipta, “Factors associated with the incidence of neonatal hyperbilirubinemia in Perinatology Ward of Wangaya General Hospital, Denpasar,” Bali Med. J., vol. 10, no. 3, pp. 1105–1110, Dec. 2021, doi: 10.15562/bmj.v10i3.2690. |
| [2] | K. S. Najib, F. Saki, F. Hemmati, and S. Inaloo, “Incidence, Risk Factors and Causes of Severe Neonatal Hyperbilirubinemia in the South of Iran (Fars Province),” Iran. Red Crescent Med. J., vol. 15, no. 3, pp. 260–3, Mar. 2013, doi: 10.5812/ircmj.3337. |
| [3] | M. Abdirahman, “HARAMAYA UNIVERSITY COLLEGE OF HEALTH AND MEDICAL SCIENCES SCHOOL OF GRADUATE STUDIES”. |
| [4] | A. Tamiru, M. Teshome, W. Akanaw, D. Guadie, and A. Woldesellassie, “Factors associated with Neonatal hyperbilirubinemia among case files of all admitted in-born and out-born neonates, Northwest Ethiopia, 2019,” Iran. J. Neonatol. IJN, no. Online First, Oct. 2020, doi: 10.22038/ijn.2020.49279.1859. |
| [5] | T. S. Almohayya, R. F. Alshabanah, and E. M. Alahmari, “Incidence and Risk Factors for Neonatal Jaundice among Neonates with Urinary Tract Infection in Abha, Saudi Arabia,” Egypt. J. Hosp. Med., vol. 67, no. 2, pp. 692–696, Apr. 2017, doi: 10.12816/0037823. |
| [6] | Y. A. Safaa Abu Mostafa, “Neonatal hyperbilirubinemia, Risk factors, Preterm, Neonatal Intensive Care Unit,” Public Health Res., 2017. |
| [7] | C. N. Onyearugha, B. N. Onyire, and H. A. A. Ugboma, “Neonatal jaundice: Prevalence and associated factors as seen in Federal Medical Centre Abakaliki, Southeast Nigeria”. |
| [8] | B. O. Olusanya, M. Kaplan, and T. W. R. Hansen, “Neonatal hyperbilirubinaemia: a global perspective,” Lancet Child Adolesc. Health, vol. 2, no. 8, pp. 610–620, Aug. 2018, doi: 10.1016/S2352-4642(18)30139-1. |
| [9] | H. G. Michael Tamene Haile, “Prevalence and Contributing Factors of Neonatal Jaundice in Neonatal Intensive Care Unit at St Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia, 2019,” J. Health Med. Nurs., May 2020, doi: 10.7176/JHMN/74-03. |
| [10] | S. Aynalem et al., “Hyperbilirubinemia in Preterm Infants Admitted to Neonatal Intensive Care Units in Ethiopia,” Glob. Pediatr. Health, vol. 7, p. 2333794X2098580, Jan. 2020, doi: 10.1177/2333794X20985809. |
| [11] | T.-C. Yu et al., “Prevalence and burden of illness of treated hemolytic neonatal hyperbilirubinemia in a privately insured population in the United States,” BMC Pediatr., vol. 19, no. 1, p. 53, Dec. 2019, doi: 10.1186/s12887-019-1414-x. |
| [12] | S. Asaye, M. Bekele, A. Getachew, D. Fufa, T. Adugna, and E. Tadese, “Hyperbilirubinemia and associated factors among neonates admitted to neonatal care unit in Jimma Medical Center,” In Review, preprint, Jun. 2022. doi: 10.21203/rs.3.rs-1805402/v1. |
| [13] | E. A. Lake, G. B. Abera, G. A. Azeze, N. A. Gebeyew, and B. W. Demissie, “Magnitude of Neonatal Jaundice and Its Associated Factor in Neonatal Intensive Care Units of Mekelle City Public Hospitals, Northern Ethiopia,” Int. J. Pediatr., vol. 2019, pp. 1–9, Apr. 2019, doi: 10.1155/2019/1054943. |
| [14] | A. D. Bizuneh, B. Alemnew, A. Getie, A. Wondmieneh, and G. Gedefaw, “Determinants of neonatal jaundice among neonates admitted to five referral hospitals in Amhara region, Northern Ethiopia: an unmatched case-control study,” BMJ Paediatr. Open, vol. 4, no. 1, p. e000830, Sep. 2020, doi: 10.1136/bmjpo-2020-000830. |
| [15] | G. G. Asefa et al., “Determinants of Neonatal Jaundice among Neonates Admitted to Neonatal Intensive Care Unit in Public General Hospitals of Central Zone, Tigray, Northern Ethiopia, 2019: a Case-Control Study,” BioMed Res. Int., vol. 2020, pp. 1–8, Oct. 2020, doi: 10.1155/2020/4743974. |
| [16] | N. Acharya and C. P. Paneru, “Prevalence and Etiology of Neonatal Jaundice in a Tertiary Care Hospital,” J. Nepalgunj Med. Coll., vol. 18, no. 2, pp. 35–38, Aug. 2021, doi: 10.3126/jngmc.v18i2.38891. |
| [17] | N. Dorji, M. R. Gurung, D. Gyeltshen, K. S. Mongar, and S. Wangmo, “Epidemiology of neonatal jaundice at Punakha District Hospital, Punakha, Bhutan,” Int. Health. |
| [18] | M. I. Mbah, H. Emmanuel, M. S. Samari, and B. T. Boshi, “Incidence and Risk Factors to Neonatal Jaundice in Jalingo, Taraba State,” J. Biosci. Med., vol. 10, no. 10, pp. 152–163, 2022, doi: 10.4236/jbm.2022.1010012. |
| [19] | C. Murekatete, C. Muteteli, R. Nsengiyumva, and G. Chironda, “Neonatal Jaundice Risk Factors at a District Hospital in Rwanda,” Rwanda J. Med. Health Sci., vol. 3, no. 2, pp. 204–213, Sep. 2020, doi: 10.4314/rjmhs.v3i2.10. |
| [20] | Y. A. Aynalem, G. B. Mulu, T. Y. Akalu, and W. S. Shiferaw, “Prevalence of neonatal hyperbilirubinaemia and its association with glucose-6-phosphate dehydrogenase deficiency and blood-type incompatibility in sub-Saharan Africa: a systematic review and meta-analysis,” BMJ Paediatr. Open, vol. 4, no. 1, p. e000750, Sep. 2020, doi: 10.1136/bmjpo-2020-000750. |
| [21] | C. Nyangabyaki-Twesigye et al., “Prevalence, factors associated and treatment outcome of hyperbilirubinaemia in neonates admitted to St Francis hospital, Nsambya, Uganda: a descriptive study,” Afr. Health Sci., vol. 20, no. 1, pp. 397–405, Apr. 2020, doi: 10.4314/ahs.v20i1.46. |
| [22] | B. Wood, P. Culley, C. Roginski, J. Powell, and J. Waterhouse, “Factors affecting neonatal jaundice.,” Arch. Dis. Child., vol. 54, no. 2, pp. 111–115, Feb. 1979, doi: 10.1136/adc.54.2.111. |
APA Style
Hussein Abiti, Abdulkerim Dedefo, Legese Lemma. (2023). Prevalence and Associated Factors of Hyperbilirubinemia Among Neonates Admitted to Neonatal Intensive Care Unit of Saint Peter Specialized Hospital, Addis Ababa, Ethiopia. Science Journal of Public Health, 11(3), 56-63. https://doi.org/10.11648/j.sjph.20231103.12
ACS Style
Hussein Abiti; Abdulkerim Dedefo; Legese Lemma. Prevalence and Associated Factors of Hyperbilirubinemia Among Neonates Admitted to Neonatal Intensive Care Unit of Saint Peter Specialized Hospital, Addis Ababa, Ethiopia. Sci. J. Public Health 2023, 11(3), 56-63. doi: 10.11648/j.sjph.20231103.12
AMA Style
Hussein Abiti, Abdulkerim Dedefo, Legese Lemma. Prevalence and Associated Factors of Hyperbilirubinemia Among Neonates Admitted to Neonatal Intensive Care Unit of Saint Peter Specialized Hospital, Addis Ababa, Ethiopia. Sci J Public Health. 2023;11(3):56-63. doi: 10.11648/j.sjph.20231103.12
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.sjph.20231103.12,
author = {Hussein Abiti and Abdulkerim Dedefo and Legese Lemma},
title = {Prevalence and Associated Factors of Hyperbilirubinemia Among Neonates Admitted to Neonatal Intensive Care Unit of Saint Peter Specialized Hospital, Addis Ababa, Ethiopia},
journal = {Science Journal of Public Health},
volume = {11},
number = {3},
pages = {56-63},
doi = {10.11648/j.sjph.20231103.12},
url = {https://doi.org/10.11648/j.sjph.20231103.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20231103.12},
abstract = {Introduction: Neonatal hyperbilirubinemia is a widespread and significant clinical problem among neonates worldwide. Globally, every year about 1.1 million babies develop it and the vast majority resides in developing countries like Ethiopia. It is a major cause of hospital neonatal intensive care unit admission and readmissions during the neonatal period. As far as our knowledge is concerned there is no such study conducted in St. peter specialized hospital so far. Hence the objective of this study is to determine Prevalence and associated factors of hyperbilirubinemia among neonates admitted to neonatal intensive care unit of Saint Peter Specialized Hospital, Addis Ababa, Ethiopia from January, 1/2022 to January 1, 2023. Methods: A Facility based Retrospective cross sectional study was conducted among one hundred forty two (142) neonates admitted at St. peter specialized hospital by using systematic random sampling technique. Data on socio-demographic characteristics and, potential associated factors for hyperbilirubinemia were collected by a structured data extraction checklist. For this study, a total serum bilirubin level ≥5 mg/dL was taken as the cutoff point to diagnose hyperbilirubinemia. Data entry was done by EPI info version 7, and analyzed using SPSS version 23.0. Binary logistic and multiple variable logistic regression models were used to identify associated factors. Association between were considered statistically significant only if A two-sided P-value Result: A total of 142 neonates were included in the study making response rate 100%. The overall prevalence of neonatal hyperbilirubinemia was 35 (24.6 %) with (95% CI: 17.6-31.7). Among several possible factors: Being male sex [AOR]:7.7, 95%CI (1.88, 32.1)], Birth trauma [AOR]: 17, 95%CI (3.8, 76.6), neonatal sepsis [AOR]: 10.9, 95%CI (2.9, 41.79)] and ABO incompatibility [AOR]: 22, 95%CI (4.7, 102.05)] were independent determinants of neonatal hyperbilirubinemia. Conclusion and recommendation: The prevalence of Neonatal Hyperbilirubinemia was quite high. Among identified associated factors for hyperbilirubinemia in this study: neonatal sex, Birth trauma, Sepsis and ABO incompatibility were the leading cause. Hence Health care provider working at NICU should undergo routine screening and investigations for TSB are imperative for early detection and timely intervention.},
year = {2023}
}
TY - JOUR T1 - Prevalence and Associated Factors of Hyperbilirubinemia Among Neonates Admitted to Neonatal Intensive Care Unit of Saint Peter Specialized Hospital, Addis Ababa, Ethiopia AU - Hussein Abiti AU - Abdulkerim Dedefo AU - Legese Lemma Y1 - 2023/05/31 PY - 2023 N1 - https://doi.org/10.11648/j.sjph.20231103.12 DO - 10.11648/j.sjph.20231103.12 T2 - Science Journal of Public Health JF - Science Journal of Public Health JO - Science Journal of Public Health SP - 56 EP - 63 PB - Science Publishing Group SN - 2328-7950 UR - https://doi.org/10.11648/j.sjph.20231103.12 AB - Introduction: Neonatal hyperbilirubinemia is a widespread and significant clinical problem among neonates worldwide. Globally, every year about 1.1 million babies develop it and the vast majority resides in developing countries like Ethiopia. It is a major cause of hospital neonatal intensive care unit admission and readmissions during the neonatal period. As far as our knowledge is concerned there is no such study conducted in St. peter specialized hospital so far. Hence the objective of this study is to determine Prevalence and associated factors of hyperbilirubinemia among neonates admitted to neonatal intensive care unit of Saint Peter Specialized Hospital, Addis Ababa, Ethiopia from January, 1/2022 to January 1, 2023. Methods: A Facility based Retrospective cross sectional study was conducted among one hundred forty two (142) neonates admitted at St. peter specialized hospital by using systematic random sampling technique. Data on socio-demographic characteristics and, potential associated factors for hyperbilirubinemia were collected by a structured data extraction checklist. For this study, a total serum bilirubin level ≥5 mg/dL was taken as the cutoff point to diagnose hyperbilirubinemia. Data entry was done by EPI info version 7, and analyzed using SPSS version 23.0. Binary logistic and multiple variable logistic regression models were used to identify associated factors. Association between were considered statistically significant only if A two-sided P-value Result: A total of 142 neonates were included in the study making response rate 100%. The overall prevalence of neonatal hyperbilirubinemia was 35 (24.6 %) with (95% CI: 17.6-31.7). Among several possible factors: Being male sex [AOR]:7.7, 95%CI (1.88, 32.1)], Birth trauma [AOR]: 17, 95%CI (3.8, 76.6), neonatal sepsis [AOR]: 10.9, 95%CI (2.9, 41.79)] and ABO incompatibility [AOR]: 22, 95%CI (4.7, 102.05)] were independent determinants of neonatal hyperbilirubinemia. Conclusion and recommendation: The prevalence of Neonatal Hyperbilirubinemia was quite high. Among identified associated factors for hyperbilirubinemia in this study: neonatal sex, Birth trauma, Sepsis and ABO incompatibility were the leading cause. Hence Health care provider working at NICU should undergo routine screening and investigations for TSB are imperative for early detection and timely intervention. VL - 11 IS - 3 ER -
Email: