Investigation on the Impact of Differently Treated PM2.5 on Cell Viability of Human Bronchial Epithelial Cells (Beas-2b) and the Construction of Bio-Hazard Index

Yuanze Liu; Qiaohui Zhang; Peiyi Xu

doi:doi:10.11648/j.sd.20180603.22

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Investigation on the Impact of Differently Treated PM2.5 on Cell Viability of Human Bronchial Epithelial Cells (Beas-2b) and the Construction of Bio-Hazard Index

Yuanze Liu, Qiaohui Zhang, Peiyi Xu

Published in Science Discovery (Volume 6, Issue 3)

Received: 25 June 2018 Published: 26 June 2018

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Abstract

After PM2.5 is inhaled by the human body, various pathogens such as influenza viruses, can cause many respiratory diseases, causing local clogging of the lungs and causing damage. At present, the research on the effect of PM2.5 on human bronchial epithelial cells (BEAS-2B) and the toxicity of the respiratory system only focuses on the single source PM2.5. The effects of different native PM2.5 on human bronchial epithelial cells (BEAS-2B) and the toxicity of the respiratory system have not been reported. In this paper, the effects of artificial PM2.5 graphene particles, sterilized atmospheric PM2.5 particles and unsterilized atmospheric PM2.5 particles on the viability of immortalized human bronchial epithelial cells (BEAS-2B) are investigated. The Bio-hazard Index describing the effects of PM2.5 on human respiratory health is constructed based on the change of BEAS-2B cell viability under different PM2.5 concentrations in the cell culture. The index can evaluate the pysiological impact of PM2.5 on the human body, and is more intuitive than the current AQI, which only discribes the physical concentration of PM2.5 in the air. The index thus provides a more accurate hazard prevention warning for susceptible population.

Published in	Science Discovery (Volume 6, Issue 3)
DOI	10.11648/j.sd.20180603.22
Page(s)	212-217
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

PM2.5, Human Bronchial Epithelial Cell, Bio-Hazard Index

References

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[2]	桑楠,岳慧峰.冬季细颗粒物对人支气管上皮细胞的毒性效应[J].山西大学学报(自然科学版), 2017,40(3):615-621。
[3]	晋小婷,苏瑞军,李卓玉.研究PM_(2.5)诱导的支气管炎症对骨髓间充质干细胞分化的影响及分子毒理[C].中国毒理学会湖北科技论坛.2015。
[4]	洪志聪,骆献阳,蔡成福,等.大气细颗粒物对人支气管上皮细胞的活性抑制和炎性作用[J].中南大学学报(医学版),2017,42(9):1042-1047。
[5]	储海燕,华秋翰,陈瑶瑶,等.中国武汉地区空气细颗粒物暴露对人支气管上皮细胞的全基因表达谱分析[C].中国环境科学学会年会.2015。
[6]	张世鑫,伍立志,陈苘,等.大气细颗粒物及其水提物对人支气管上皮细胞的氧化损伤效应[J].预防医学, 2016, 28(4):332-335。
[7]	李娟,杨维超,洪丽娟,等.PM_(2.5)对BEAS-2B细胞脂质过氧化损伤作用[J].中国公共卫生,2014,30(11):1389-1391。
[8]	芮魏.PM2.5污染特征及其对BEAS-2B和EA.hy926细胞的分子毒性研究[D].中国科学院大学,2015。
[9]	孙琦.论空气污染对人体健康的影响及防治措施[C]//2013中国环境科学学会学术年会论文集(第七卷).2013。
[10]	常福聚,赵庆夏.人类呼吸道粘液[J].国际呼吸杂志,1986(4)。

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APA Style

Yuanze Liu, Qiaohui Zhang, Peiyi Xu. (2018). Investigation on the Impact of Differently Treated PM2.5 on Cell Viability of Human Bronchial Epithelial Cells (Beas-2b) and the Construction of Bio-Hazard Index. Science Discovery, 6(3), 212-217. https://doi.org/10.11648/j.sd.20180603.22

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ACS Style

Yuanze Liu; Qiaohui Zhang; Peiyi Xu. Investigation on the Impact of Differently Treated PM2.5 on Cell Viability of Human Bronchial Epithelial Cells (Beas-2b) and the Construction of Bio-Hazard Index. Sci. Discov. 2018, 6(3), 212-217. doi: 10.11648/j.sd.20180603.22

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AMA Style

Yuanze Liu, Qiaohui Zhang, Peiyi Xu. Investigation on the Impact of Differently Treated PM2.5 on Cell Viability of Human Bronchial Epithelial Cells (Beas-2b) and the Construction of Bio-Hazard Index. Sci Discov. 2018;6(3):212-217. doi: 10.11648/j.sd.20180603.22

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@article{10.11648/j.sd.20180603.22,
  author = {Yuanze Liu and Qiaohui Zhang and Peiyi Xu},
  title = {Investigation on the Impact of Differently Treated PM2.5 on Cell Viability of Human Bronchial Epithelial Cells (Beas-2b) and the Construction of Bio-Hazard Index},
  journal = {Science Discovery},
  volume = {6},
  number = {3},
  pages = {212-217},
  doi = {10.11648/j.sd.20180603.22},
  url = {https://doi.org/10.11648/j.sd.20180603.22},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20180603.22},
  abstract = {After PM2.5 is inhaled by the human body, various pathogens such as influenza viruses, can cause many respiratory diseases, causing local clogging of the lungs and causing damage. At present, the research on the effect of PM2.5 on human bronchial epithelial cells (BEAS-2B) and the toxicity of the respiratory system only focuses on the single source PM2.5. The effects of different native PM2.5 on human bronchial epithelial cells (BEAS-2B) and the toxicity of the respiratory system have not been reported. In this paper, the effects of artificial PM2.5 graphene particles, sterilized atmospheric PM2.5 particles and unsterilized atmospheric PM2.5 particles on the viability of immortalized human bronchial epithelial cells (BEAS-2B) are investigated. The Bio-hazard Index describing the effects of PM2.5 on human respiratory health is constructed based on the change of BEAS-2B cell viability under different PM2.5 concentrations in the cell culture. The index can evaluate the pysiological impact of PM2.5 on the human body, and is more intuitive than the current AQI, which only discribes the physical concentration of PM2.5 in the air. The index thus provides a more accurate hazard prevention warning for susceptible population.},
 year = {2018}
}

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TY  - JOUR
T1  - Investigation on the Impact of Differently Treated PM2.5 on Cell Viability of Human Bronchial Epithelial Cells (Beas-2b) and the Construction of Bio-Hazard Index
AU  - Yuanze Liu
AU  - Qiaohui Zhang
AU  - Peiyi Xu
Y1  - 2018/06/26
PY  - 2018
N1  - https://doi.org/10.11648/j.sd.20180603.22
DO  - 10.11648/j.sd.20180603.22
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 212
EP  - 217
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20180603.22
AB  - After PM2.5 is inhaled by the human body, various pathogens such as influenza viruses, can cause many respiratory diseases, causing local clogging of the lungs and causing damage. At present, the research on the effect of PM2.5 on human bronchial epithelial cells (BEAS-2B) and the toxicity of the respiratory system only focuses on the single source PM2.5. The effects of different native PM2.5 on human bronchial epithelial cells (BEAS-2B) and the toxicity of the respiratory system have not been reported. In this paper, the effects of artificial PM2.5 graphene particles, sterilized atmospheric PM2.5 particles and unsterilized atmospheric PM2.5 particles on the viability of immortalized human bronchial epithelial cells (BEAS-2B) are investigated. The Bio-hazard Index describing the effects of PM2.5 on human respiratory health is constructed based on the change of BEAS-2B cell viability under different PM2.5 concentrations in the cell culture. The index can evaluate the pysiological impact of PM2.5 on the human body, and is more intuitive than the current AQI, which only discribes the physical concentration of PM2.5 in the air. The index thus provides a more accurate hazard prevention warning for susceptible population.
VL  - 6
IS  - 3
ER  -

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Author Information

Yuanze Liu

Shanghai World Foreign Language Academy, Shanghai, China
Qiaohui Zhang

Shanghai World Foreign Language Academy, Shanghai, China
Peiyi Xu

Shanghai World Foreign Language Academy, Shanghai, China

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Plain Text BibTeX RIS

APA Style

Yuanze Liu, Qiaohui Zhang, Peiyi Xu. (2018). Investigation on the Impact of Differently Treated PM2.5 on Cell Viability of Human Bronchial Epithelial Cells (Beas-2b) and the Construction of Bio-Hazard Index. Science Discovery, 6(3), 212-217. https://doi.org/10.11648/j.sd.20180603.22

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ACS Style

Yuanze Liu; Qiaohui Zhang; Peiyi Xu. Investigation on the Impact of Differently Treated PM2.5 on Cell Viability of Human Bronchial Epithelial Cells (Beas-2b) and the Construction of Bio-Hazard Index. Sci. Discov. 2018, 6(3), 212-217. doi: 10.11648/j.sd.20180603.22

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AMA Style

Yuanze Liu, Qiaohui Zhang, Peiyi Xu. Investigation on the Impact of Differently Treated PM2.5 on Cell Viability of Human Bronchial Epithelial Cells (Beas-2b) and the Construction of Bio-Hazard Index. Sci Discov. 2018;6(3):212-217. doi: 10.11648/j.sd.20180603.22

Copy | Download

@article{10.11648/j.sd.20180603.22,
  author = {Yuanze Liu and Qiaohui Zhang and Peiyi Xu},
  title = {Investigation on the Impact of Differently Treated PM2.5 on Cell Viability of Human Bronchial Epithelial Cells (Beas-2b) and the Construction of Bio-Hazard Index},
  journal = {Science Discovery},
  volume = {6},
  number = {3},
  pages = {212-217},
  doi = {10.11648/j.sd.20180603.22},
  url = {https://doi.org/10.11648/j.sd.20180603.22},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20180603.22},
  abstract = {After PM2.5 is inhaled by the human body, various pathogens such as influenza viruses, can cause many respiratory diseases, causing local clogging of the lungs and causing damage. At present, the research on the effect of PM2.5 on human bronchial epithelial cells (BEAS-2B) and the toxicity of the respiratory system only focuses on the single source PM2.5. The effects of different native PM2.5 on human bronchial epithelial cells (BEAS-2B) and the toxicity of the respiratory system have not been reported. In this paper, the effects of artificial PM2.5 graphene particles, sterilized atmospheric PM2.5 particles and unsterilized atmospheric PM2.5 particles on the viability of immortalized human bronchial epithelial cells (BEAS-2B) are investigated. The Bio-hazard Index describing the effects of PM2.5 on human respiratory health is constructed based on the change of BEAS-2B cell viability under different PM2.5 concentrations in the cell culture. The index can evaluate the pysiological impact of PM2.5 on the human body, and is more intuitive than the current AQI, which only discribes the physical concentration of PM2.5 in the air. The index thus provides a more accurate hazard prevention warning for susceptible population.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Investigation on the Impact of Differently Treated PM2.5 on Cell Viability of Human Bronchial Epithelial Cells (Beas-2b) and the Construction of Bio-Hazard Index
AU  - Yuanze Liu
AU  - Qiaohui Zhang
AU  - Peiyi Xu
Y1  - 2018/06/26
PY  - 2018
N1  - https://doi.org/10.11648/j.sd.20180603.22
DO  - 10.11648/j.sd.20180603.22
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 212
EP  - 217
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20180603.22
AB  - After PM2.5 is inhaled by the human body, various pathogens such as influenza viruses, can cause many respiratory diseases, causing local clogging of the lungs and causing damage. At present, the research on the effect of PM2.5 on human bronchial epithelial cells (BEAS-2B) and the toxicity of the respiratory system only focuses on the single source PM2.5. The effects of different native PM2.5 on human bronchial epithelial cells (BEAS-2B) and the toxicity of the respiratory system have not been reported. In this paper, the effects of artificial PM2.5 graphene particles, sterilized atmospheric PM2.5 particles and unsterilized atmospheric PM2.5 particles on the viability of immortalized human bronchial epithelial cells (BEAS-2B) are investigated. The Bio-hazard Index describing the effects of PM2.5 on human respiratory health is constructed based on the change of BEAS-2B cell viability under different PM2.5 concentrations in the cell culture. The index can evaluate the pysiological impact of PM2.5 on the human body, and is more intuitive than the current AQI, which only discribes the physical concentration of PM2.5 in the air. The index thus provides a more accurate hazard prevention warning for susceptible population.
VL  - 6
IS  - 3
ER  -

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