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Parkinson's Disease Diagnosis with I Ioflupane (DaTSCAN)

Received: 20 August 2024     Accepted: 5 September 2024     Published: 23 September 2024
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Abstract

The authors of the paper statistically evaluated the results of single photon emission computed tomography (SPECT) brain scans in 1050 patients with suspected Parkinson's disease. The control group consisted of patients with other neurological diseases who underwent SPECT brain scans. Diagnosis of Parkinson's disease based on clinical examination is not always straightforward. An examination of the transport dopaminergic route by Ioflupane (123I) helps to refine the diagnosis. Based on the obtained results, the authors believe that in the differential diagnosis of Parkinson's disease (or Parkinson's syndrome), SPECT brain imaging is of unmistakable importance, both from a clinical, therapeutic and socioeconomic point of view. In Parkinson's disease, the functional state of the autonomic nervous system (ANS) changes. Examination of the ANS can help both in the differential diagnosis of Parkinsonian syndromes and in determining the degree of impairment; it is a prognostic indicator. Results of Single Photon Emission Computed Tomography (SPECT) examinations were statistically evaluated in the group of 1050 patients with suspected Parkinson´s disease. SPECT examinations of patients with other neurological diseases were used as a control group. Diagnosis of Parkinson's disease based on clinical examination is not always straightforward. An examination of the transport dopaminergic route by Ioflupane (123I) helps to refine the diagnosis. After statistical evaluation of these results authors believe that in the differential diagnosis of Parkinson's disease (or Parkinson's syndrome), SPECT brain imaging is of huge importance from a clinical, therapeutic and socioeconomic point of view. In Parkinson's disease, the functional state of the autonomic nervous system changes. Examination of the autonomic nervous system can help both in the differential diagnosis and in determining the degree of impairment.

Published in American Journal of Internal Medicine (Volume 12, Issue 4)
DOI 10.11648/j.ajim.20241204.11
Page(s) 40-55
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Parkinson's Disease, Parkinson's Syndrome, SPECT of the Brain, Autonomic Nervous System

References
[1] Mariani G., Flotats A., Israel O., Kim E. E., Kuwert T. (2008). Clinical Applications of SPECT/CT: New Hybrid Nuclear Medicine Imaging System. IAEA, Vienna, 2008, p. 55.
[2] Lepej J., Lacko A. (2018). Nukleárna Medicína. 1. Všeobecná časť [Nuclear Medicine. 1. General part]. Equilibria, s.r.o., Košice, 2018, p. 202. ISBN 978-80-8143-222-4.
[3] Kovacs N., Kovács T., Bokor M., Tamás G., Dibó G., Nagy F., Takáts A., Varannai L., Óváry C., Klivényi P. (2023). A Parkinson-kór és az egyéb parkinsonizmusok kivizsgálása és kezelése. A MTPT Szakmai ajánlása. MTPT [Examination and treatment of Parkinson's disease and other parkinsonisms]. jóváhagyás dátuma: március 23. [online]. [cit. 23. March 2023]. Available at:
[4] Andert L. (2010). Automatická fúze a registrace snímků SPECT a CT [Automatic fusion and registration of SPECT and CT images]. Plzeň: Západočeská univerzita v fakulta aplikovaných Plzni, věd, katedra matematiky, diplomová práca, 2010. p. 54.
[5] Hidasi E. (2010). A Parkinson-kór modern szemlélete. [A modern view of Parkinson's disease]. LAM 2010; 20(12): 825–829.
[6] Pirker W., Brücke T. (2004). SPECT in der diagnostik von Parkinson-Syndromen. Journal für Neurologie, 2004, 5(2): p 9-20.
[7] Sawires M., Berek K. (2012). Morbus Parkinson – Pharmakotherapie. [online]. [cit. 2012-05-21].
[8] Borbely K. (2010). Neuro-SPECT ÉS PET: további lehetőségek. PET/CT: alkalmazások és feltételei [Neuro-SPECT AND PET: additional options. PET/CT: applications and conditions MTA]. doktori értekezés tézisei. Országos Onkológiai Intézet. Budapest, 2010.
[9] Takats A. (2003). A Parkinson-kór diagnosztikai kritériumai és differenciáldiagnosztikája. [Diagnostic criteria and differential diagnosis of Parkinson's disease]. Clin Neurosci/Ideggy Szle 2003; 56(5–6): p. 144–154.
[10] Lacko A., Straka J., Tupý J., Hruboň A., Madarász Š., Podoba J et al. (2021). Využitie metód nukleárnej medicíny v diagnostike funkčných zmien kardiovaskulárneho systému [The use of nuclear medicine methods in the diagnosis of functional changes in the cardiovascular system]. Slovac Academic Press, 2021, p. 240. ISBN 978-80-89607-95-2.
[11] Hegarova M. (2009). Patofyziologie klinického syndromu srdečního selhání [Pathophysiology of the clinical syndrome of heart failure] In: VOJÁČEK J., KETTNER J.: Klinická kardiologie. Hradec králové: Nucleus 2009, p. 357-378.
[12] Taegtmeyer H., Dilsizian V. ä2009). Imaging Cardiac Metabolism. In: DILSIZIAN, V., NARULA, J.,: Atlas of Nuclear Cardiology. Philadelphia: Springer 2009: p. 182-200.
[13] Schwaiger M., Saraste A., Bengel F. (2009). Myocardial Innervation. In Dilsizian V, Narula J. Atlas of Nuclear Cardiology. Philadelphia: Springer 2009: 243-255.
[14] Lacko A., Mokáň M., Bestvina D., Chalachánová I., Valko P., Čombor I. (2007). Nové trendy v nukleárnej medicine [New trends in nuclear medicine]. Vyd. Turany: P + M. 2007. p. 79.
[15] Opavsky J. (2002). Autonomní nervový systém a diabetická autonomní neuropatie [The autonomic nervous system and diabetic autonomic neuropathy]. Praha: Galén, 2002, p. 304.
[16] Szatmari S. (2020). A Parkinson-kór epidemiológiája és a prodromális fázisában előforduló kórképek [Epidemiology of Parkinson's disease and symptoms occurring in the prodromal phase]. Doktori értekezés. Semmelweis Egyetem Szentágothai János Idegtudományi Doktori Iskola. Budapest. 2020. [online]. [cit. 9. March 2023]. Available at:
[17] Faludi B., Janszky J., Komoly S., Kovács N. (2015). Sleep disturbances in Parkinson’s disease: characteristics, evaluation and therapeutic approaches. Orv. Hetil., 2015, 156(27), 1091–1099.
[18] Kovac M. (2020). Nem-motoros tünetek klinikai vizsgálata Parkinson-kórban [Clinical examination of non-motor symptoms in Parkinson's disease]. Egyetemi Doktori Értekezés. Pécsi Tudományegyetem Általános Orvostudományi Kar, Pécs. 2020. [online]. [cit. 9. March 2023]. Available at:
[19] Minar M., Valkovic P. (2012). Aktuálne trendy v liečbe Parkinsonovej choroby [Current trends in the treatment of Parkinson's disease]. Časopis MediNEWS, Edukafarm, 1/2012, p. 52-54.
[20] Scherfler, Ch et al. (2007). Role of DAT-SPECT in the diagnostic work up of parkinsonism. Movement disorders: official journal of the Movement Disorder Society, 2007, 22.9: 1229-1238.
[21] Madarasz S. (2010). Trojfázová rehabilitácia pacientov s Parkinsonovou chorobou [Three-phase rehabilitation of patients with Parkinson's disease]. Physiotherapia Slovaca. Časopis pre fyzioterapiu, balneológiu a liečebnú rehabilitáciu, vol. 1, 2010, No. 1, p. 22-30.
[22] Kurcova S., Mensikova K., Kaiserova M., Kurca E., Tuckova L., Kanovsky P. (2016). Pre-motorické a non-motorické príznaky Parkinsonovej choroby – taxonómia, klinická manifestácia a neuropatologické koreláty [Pre-motor and non-motor symptoms of Parkinson's disease - taxonomy, clinical manifestation and neuropathological correlates]. Cesk Slov Neurol N 2016; 79/ 112(3): 255–270.
[23] Nagamachi S, Jinnouchi S. (1988). 123I-MIBG Myocardial Scintigraphy in Diabetes Patients: relation –ship with 201Tl Uptake and Cardial Autonomic Function. Ann. Nucl. Med. 1988; 12: p. 323-331.
[24] Ukropcová B., Straka I., Ukropec J., Kovacsova E., Duranikova O., Kulcsarova K., Gombosova L., Forisek-Paulova P., Sedliak M., Skorvanek M. (2021). Nefarmakologická prevencia a liečba neurodegeneratívnych ochorení. Pohybové, kognitívne a nutričné intervencie v prevencii progresie Parkinsonovej choroby [Non-pharmacological prevention and treatment of neurodegenerative diseases. Movement, cognitive and nutritional interventions in the prevention of progression of Parkinson's disease]. Štandardný postup MZ SR [online]. [cit. 9. March 2023]. Available at:
[25] Mravec B. (2013). Nervový systém: patofyziológia. [Nervous system: pathophysiology]. Skriptum pre študentov lekárskych fakúlt. SAP, Bratislava 2013, 132 p.
[26] Roth J. (2016). Parkinsonova nemoc není prionové onemocnění [Parkinson's disease is not a prion disease]. Cesk Slov Ne urol N 2016; 79/ 112(1): 22–24.
[27] Hartl F. U. (2017). Protein Misfolding Diseases. Annu. Rev. Biochem. 2017. 86: 21–26.
[28] Poewe W., Seppi K., Tanner C. T., Halliday G. M., Brundin P., Volkmann J., Schrag A. E. And Lang A. E. (2017). Parkinson disease. Nature Reviews | Disease Primers Volume 3 | Article Number 17013 | p. 1-21. 693-713.
[29] Petrleničová D., Gmitterová K., Benetin J. (2010). Mechanizmy neurodegenerácie pri Parkinsonovej chorobe [Mechanisms of neurodegeneration in Parkinson's disease]. Cesk Slov Ne urol N 2010; 73/ 106(4): 645–649.
[30] Wilson Iii D. M., Cookson M. R., Bosch L. V. D., Zetterberg H., Holtzman D. M., And Dewachter I. (2023). Hallmarks of neurodegenerative diseases. Cell 186, February 16, 2023, p. 31.
[31] Berg D., Postuma R. B., Bloem B., Chan P., Dubois B., Gasser T., Goetz C. G., Halliday G. M., Hardy J., Lang A. E., Litvan I., Marek K., Obeso J., Oertel W., Olanow C. V., Poewe W., Stern M., Deuschl G. (2014). Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease. Movement Disorders, Vol. 29, No. 4, 2014, p. 454-462.
[32] Postuma R. B., Berg D., Stern M., Poewe W., Olanow C. W., Oertel W., Obeso J., Marek K., Litvan I., Lang A. E., Halliday G., Goetz C. G., Gasser T., Dubois B., Chan P., Bastiaan R., Bloem B. R., Adler C. H., Deuschl G. (2015). MDS clinical diagnostic criteria for Parkinson's disease. MDS Clinical Diagnostic Criteria for Parkinson’s Disease. Movement Disorders, Vol. 30, No. 12, 2015.
[33] Mosejová A., Škorvánek M. (2019). Parkinsonova choroba [Parkinson's disease]. InVitro 02/2019 p. 84-89.
[34] Kurcova S. (2020). Non-motorické príznaky Parkinsonovej choroby a ich ovplyvnenie systémom hlbokej mozgovej stimulácie subthalamického jadra. [Non-motor symptoms of Parkinson's disease and their influence by the deep brain stimulation system of the subthalamic nucleus]. Dissertation, Department of Neurology, Olomouc, 2020, p. 156.
[35] Kusnirova A., Straka I., Valkovic P. (2016). Ako diagnostikovať Parkinsonovu chorobu v ambulancii všeobecného lekára [How to diagnose Parkinson's disease in a general practitioner's office]. Via pract., 2016, 13(6): 256–258.
[36] Geut H., Hepp D. H., Foncke E., Berendse H. W., Rozemuller J. M., Huitinga I., Berg, W. D. J. (2020). Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series. Acta Neuropathol. Commun., vol. 8, no. 1, p. Mar. 2020.
[37] Brozova H. (2021). Parkinsonova nemoc – stanovení diagnózy neurologem [Parkinson's disease - diagnosis by a neurologist]. Prolékaře.cz [online]. 2021, [cit. 2021-6-19]. Available at:
[38] Bartosova T., Klempir J. (2020). Progresivní supranukleární obrna [Progressive supranuclear palsy]. Cesk Slov Neurol Neurochir. 2020; 83/ 116(6): 584– 601.
[39] Rascovsky K., Hodges J. R., Knopman D., Mendez M. F., Kramer J. H., Neuhaus J et al. (2011). Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 2011: 134; 2456–2477.
[40] Grofik M. (2022). Diagnostika parkinsonských syndrómov v klinickej praxis [Diagnosis of parkinsonian syndromes in clinical practice]. Lekárske noviny, November/2022, p. 14.
[41] Valkovic P., Benetin J. (2011). Tremor z pohľadu klinického neurológa [Tremor from the point of view of a clinical neurologist]. Neurol. pro praxi 2011; 12(1): p. 12–15.
[42] Ting-Li S., Dendi R., Goldstein D. (2002). Progressive Loss of Cardiac Sympathetic Inervation in Parkinson´s Disease. Ann. Neurol. 2002; 52: 220-223.
[43] Roth J., Sekyrová M., Ružička E., Dvorák J., Kaňovský P., Rektorová I. (2005). Parkinsonova nemoc. [Parkinson's disease]. Third expanded edition. Praha: Maxdorf, 2005.
[44] Roth J., Havrankova P. (2008). Parkinsonské syndromy v griatrické praxi: diferenciálně diagnostický algorytmus [Parkinsonian syndromes in geriatric practice: a differential diagnostic algorithm]. Čes. ger. rev. 2008; 6(4): p. 220-226.
[45] Valis M., Masopust J., Talab R., Konupcíková K., Hosak L. (2010). 123I-FP-CIT SPECT odlíší Parkinsonovú chorobu od parkinsonismu navodeného léky–dvě kazuistiky [123I-FP-CIT SPECT differentiates Parkinson's disease from drug-induced parkinsonism—two case reports]. Čes. a slov. Psychiatr. 2010; 106(1): p. 42-45.
Cite This Article
  • APA Style

    Lacko, A., Madarasz, S., Kolejak, K., Babecka, J., Lackova, L. (2024). Parkinson's Disease Diagnosis with I Ioflupane (DaTSCAN). American Journal of Internal Medicine, 12(4), 40-55. https://doi.org/10.11648/j.ajim.20241204.11

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    ACS Style

    Lacko, A.; Madarasz, S.; Kolejak, K.; Babecka, J.; Lackova, L. Parkinson's Disease Diagnosis with I Ioflupane (DaTSCAN). Am. J. Intern. Med. 2024, 12(4), 40-55. doi: 10.11648/j.ajim.20241204.11

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    AMA Style

    Lacko A, Madarasz S, Kolejak K, Babecka J, Lackova L. Parkinson's Disease Diagnosis with I Ioflupane (DaTSCAN). Am J Intern Med. 2024;12(4):40-55. doi: 10.11648/j.ajim.20241204.11

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  • @article{10.11648/j.ajim.20241204.11,
      author = {Anton Lacko and Stefan Madarasz and Kamil Kolejak and Jozef Babecka and Lucia Lackova},
      title = {Parkinson's Disease Diagnosis with I Ioflupane (DaTSCAN)
    },
      journal = {American Journal of Internal Medicine},
      volume = {12},
      number = {4},
      pages = {40-55},
      doi = {10.11648/j.ajim.20241204.11},
      url = {https://doi.org/10.11648/j.ajim.20241204.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20241204.11},
      abstract = {The authors of the paper statistically evaluated the results of single photon emission computed tomography (SPECT) brain scans in 1050 patients with suspected Parkinson's disease. The control group consisted of patients with other neurological diseases who underwent SPECT brain scans. Diagnosis of Parkinson's disease based on clinical examination is not always straightforward. An examination of the transport dopaminergic route by Ioflupane (123I) helps to refine the diagnosis. Based on the obtained results, the authors believe that in the differential diagnosis of Parkinson's disease (or Parkinson's syndrome), SPECT brain imaging is of unmistakable importance, both from a clinical, therapeutic and socioeconomic point of view. In Parkinson's disease, the functional state of the autonomic nervous system (ANS) changes. Examination of the ANS can help both in the differential diagnosis of Parkinsonian syndromes and in determining the degree of impairment; it is a prognostic indicator. Results of Single Photon Emission Computed Tomography (SPECT) examinations were statistically evaluated in the group of 1050 patients with suspected Parkinson´s disease. SPECT examinations of patients with other neurological diseases were used as a control group. Diagnosis of Parkinson's disease based on clinical examination is not always straightforward. An examination of the transport dopaminergic route by Ioflupane (123I) helps to refine the diagnosis. After statistical evaluation of these results authors believe that in the differential diagnosis of Parkinson's disease (or Parkinson's syndrome), SPECT brain imaging is of huge importance from a clinical, therapeutic and socioeconomic point of view. In Parkinson's disease, the functional state of the autonomic nervous system changes. Examination of the autonomic nervous system can help both in the differential diagnosis and in determining the degree of impairment.
    },
     year = {2024}
    }
    

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  • TY  - JOUR
    T1  - Parkinson's Disease Diagnosis with I Ioflupane (DaTSCAN)
    
    AU  - Anton Lacko
    AU  - Stefan Madarasz
    AU  - Kamil Kolejak
    AU  - Jozef Babecka
    AU  - Lucia Lackova
    Y1  - 2024/09/23
    PY  - 2024
    N1  - https://doi.org/10.11648/j.ajim.20241204.11
    DO  - 10.11648/j.ajim.20241204.11
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 40
    EP  - 55
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20241204.11
    AB  - The authors of the paper statistically evaluated the results of single photon emission computed tomography (SPECT) brain scans in 1050 patients with suspected Parkinson's disease. The control group consisted of patients with other neurological diseases who underwent SPECT brain scans. Diagnosis of Parkinson's disease based on clinical examination is not always straightforward. An examination of the transport dopaminergic route by Ioflupane (123I) helps to refine the diagnosis. Based on the obtained results, the authors believe that in the differential diagnosis of Parkinson's disease (or Parkinson's syndrome), SPECT brain imaging is of unmistakable importance, both from a clinical, therapeutic and socioeconomic point of view. In Parkinson's disease, the functional state of the autonomic nervous system (ANS) changes. Examination of the ANS can help both in the differential diagnosis of Parkinsonian syndromes and in determining the degree of impairment; it is a prognostic indicator. Results of Single Photon Emission Computed Tomography (SPECT) examinations were statistically evaluated in the group of 1050 patients with suspected Parkinson´s disease. SPECT examinations of patients with other neurological diseases were used as a control group. Diagnosis of Parkinson's disease based on clinical examination is not always straightforward. An examination of the transport dopaminergic route by Ioflupane (123I) helps to refine the diagnosis. After statistical evaluation of these results authors believe that in the differential diagnosis of Parkinson's disease (or Parkinson's syndrome), SPECT brain imaging is of huge importance from a clinical, therapeutic and socioeconomic point of view. In Parkinson's disease, the functional state of the autonomic nervous system changes. Examination of the autonomic nervous system can help both in the differential diagnosis and in determining the degree of impairment.
    
    VL  - 12
    IS  - 4
    ER  - 

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