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Extragenital Pathology and Immunocompetent Cells Relations of Lactating Breast Gland and Offspring Jejunum

Received: 21 March 2022     Accepted: 9 April 2022     Published: 26 April 2022
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Abstract

Researched the effect of chronic toxic maternal hepatitis on the cytometric features of immunocompetent cells (ICCls) of mammary gland tissues of the female and the jejunum of the offspring during breastfeeding. For morphological researches, pieces of the right inguinal mammary gland of female outbred rats with heliotrine hepatitis and the jejunum of the lean intestine of the offspring on days 1, 3, 7, 15 and 21 of lactation were used. Cytometric researches were carried out on semi-thin sections stained with methylene blue and pyronin G. It was established that in the last stages of pregnancy and in the first week after the onset of lactation, there is an increase in migration to the terminal secretory sections of the mammary gland of the ICCls, which indicates the participation of the mammary glands in the transfer of adoptive immunity to offspring and in maintaining the immune homeostasis of the small intestine, which decreases as the immune apparatus of the small intestine develops. A decrease in the number of ICCls migrating to the lactating mammary gland in case of mother's CTH negatively affects both immune adaptation and the structural and functional development and maturation of the immune apparatus of the jejunum of the offspring during breastfeeding.

Published in American Journal of Internal Medicine (Volume 10, Issue 2)
DOI 10.11648/j.ajim.20221002.12
Page(s) 28-33
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Hepatitis, Mammary Gland, Lactation, Small Intestine, Offspring, Immunocompetent Cells

References
[1] Abdullayev N. KH., Karimov KH. YA. Pechen' pri intoksikatsii gepatotropnymi yadami. - T.: Meditsina. -1989. - 140 s.
[2] Adilbekova D. B. Postnatal'noye stanovleniye sosudnsto-tkanevykh struktur zheludka i kishechnika potomstva v usloviyakh khronicheskogo toksicheskogo gepatita u materi: Avtoref.dis. / dokt.med.nauk.- [Mesto zashchity: TMA "Tashkentskaya meditsinskaya akademiya"] Tashkent. 201S. - 62 str.
[3] Azizov, Ye. Kh. Strukturno-funktsional'nyye osnovy reaktsii mezenterial'nykh limfaticheskikh uzlov pri eksperimental'nom khronicheskom toksicheskom gepatite i puti yeye korrektsii: avtoreferat dis.... kandidata meditsinskikh nauk: 14.00.23. - Tashkent, 1996. - 19 c.: il.
[4] Bryukhin G. V., Fedosov A. A. Kharakteristika proliferativnoy aktivnosti timotsitov i limfotsitov perifericheskoy krovi potomstva samok s khronicheskim eksperimental'nym porazheniyem pecheni razlichnoy etiologii. Morfologiya. 2006. – Tom 129, №1. – S. 57-59.
[5] Zakharova I. N., Kuchina A. Ye. Mikrobiota grudnogo moloka (predstavleniye, istochniki, rol' bakteriy dlya rebenka i materi). Meditsinskiy sovet. 2022; 16 (1): 27–35. https://doi.org/10.21518/2079-701X-2022-16-1-27-35.
[6] Prikhod'ko Ye. A., Belyayeva I. A., Kruglyakov A. Yu., Mikheyeva A. A., Gorev V. V. / Faktory, assotsiirovannyye s isklyuchitel'no grudnym vskarmlivaniyem pozdnikh nedonoshennykh detey v neonatal'nom statsionare: odnomomentnoye issledovaniye // Сurrent pediatrics. – 2022, V. 21, № 1. – P. 18-24.16.
[7] Yuldashev A. YU., Rakhmatova M. KH., Tarinova M. V. Funktsional'naya morfologiya slizistoy obolochki tonkoy kishki i osobennosti yeyo adaptatsii. International Scientific and Practical Conference “WORLD SCIENCE” ISSN 2413-1032. № 4 (20), Vol. 6, April 2017 http://ws-conference.com/ - C. 38-43.
[8] Akers, R. M. (2016). Lactation and the mammary gland. John Wiley & Sons.
[9] Azimova S. B. Morphofunctional Characteristic of thymus under exposure to various environmental factors //An International Multidisciplinary Research Journal Vol. 11, Issue 3, March 2021.
[10] Azizova F. X., and others. Structural and functional properties of mesenteric lymph nodes under antigenic influence in early postnatal ontogeny. / / Uzbekistan Medical Journal. 1997: 10-11: 14-16.
[11] Berdiyorova S., Nuritdinova D., Kucharova L. S. The influence of malnutrition during the period of lactotrophic nutrition on the formation of digestion in growing rats / Berdiyorova S., Nuritdinova D., Kucharova L. S. // Infection, immunity and pharmacology. - 2019. - No. 2. - p. 311-312.
[12] Denis, M., Lacy-Hulbert, S. J., Buddle, B. M., Williamson, J. H., & Wedlock, D. N. (2011). Streptococcus uberis-specific T cells are present in mammary gland secretions of cows and can be activated to kill S. uberis. Veterinary research communications, 35 (3), 145-156.
[13] Donovan S. M. The Role of Lactoferrin in Gastrointestinal and Immune Development and Function: A Preclinical Perspective. The journal of pediatrics. www.jpeds.com Vol. 173S June, 2016. – Р. 16-28. http://dx.doi.org/10.1016/j.jpeds.2016.02.072
[14] Dynamics of antibodies to individual antigens of the hepatitis С virus in children of the first years of life / Nikolaeva LI, Goroshanskaya MN. Cherediiichenko TV. et al. // Children's infections. 2005. - No. 4. - S. 15-17.
[15] Frolov, V. M., Germanov, V. T., & Peresadin, N. A. (1991). Functional state of the hepatobiliary system and immune status of pregnant women who have had viral hepatitis. Akusherstvo i Ginekologiia, (9), 24-26.
[16] Georgountzou A., and Papadopoulos N. G. (2017) Postnatal innate immune development: from birth to adulthood. Review. Frontiers in Immunology. www.frontiersin.org - published: 11 August 2017, doi: 10.3389/fimmu.2017.00957. P. 16.
[17] Gherghiceanu, M., & Popescu, L. M. (2005). Interstitial Cajal-like cells (ICLC) in human resting mammary gland stroma. Transmission electron microscope (TEM) identification. Journal of cellular and molecular medicine, 9 (4), 893-910.
[18] Goldman, A. S. (2012). Evolution of immune functions of the mammary gland and protection of the infant. Breastfeeding Medicine, 7 (3), 132-142.
[19] Hassiotou F, Hepworth AR, Metzger P, Lai C-T, Trengove N, Hartmann PE, Filgueira L. Maternal and infant infections stimulate a rapid leukocyte response in breastmilk. Clin Transl Immunology 2013; 2: e3.
[20] Hassiotou, F., & Geddes, D. T. (2015). Immune cell–mediated protection of the mammary gland and the infant during breastfeeding. Advances in Nutrition, 6 (3), 267-275.
[21] Hine, B. C., Hunt, P. W., & Colditz, I. G. (2019). Production and active transport of immunoglobulins within the ruminant mammary gland. Veterinary immunology and immunopathology, 211, 75-84.
[22] Jin YY, Wei Z, Cao RM, Xi W, Wu SM, Chen TX. Characterization of immunocompetent cells in human milk of Han Chinese. J Hum Lact 2011; 27 (2): 155–62.
[23] Kent J. C., Christen L., Hassiotou F., Hartmann P. E. Role of breast milk. In: Patole S, editor. Nutrition for the preterm neonate. The Netherlands: Springer, 2013: 311–35.
[24] Khasanov B. B. Structural and functional features of immunocompetent breast cells glands during pregnancy and lactation in chronic hepatitis / B. B. Khasanov. // Psychology and Education. – 2021. – Vol. 58 (2). – P. 8038-8045.
[25] Khasanov, B. (2021). Maternal toxic hepatitis, structural and functional formation of the lean intestine of the offspring in the dynamics of early postnatal ontogenesis. The Scientific Heritage, (78-2), 33-37.
[26] Martinson, H. A., Jindal, S., Durand-Rougely, C., Borges, V. F., & Schedin, P. (2015). Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progression. International Journal of Cancer, 136 (8), 1803-1813.
[27] Nagamatsu T., Danny J. Schust D. J. The immunomodulatory roles of macrophages at the maternal–fetal interface. Reprod. Sci. 2010, 17 (3), 209-218.
[28] Newman J. How Breast Milk Protects Newborns // Кellymom. 2011. https://kellymom.com/pregnancy/bf-ep/how_breastmilk_protects_newborns/
[29] Ninkina, N., Kukharsky, M. S., Hewitt, M. V., Lysikova, E. A., Skuratovska, L. N., Deykin, A. V., & Buchman, V. L. (2019). Stem cells in human breast milk. Human Cell, 32 (3), 223-230.
[30] Pedersen SH, Wilkinson AL, Andreasen A, et al. Longitudinal analysis of mature breastmilk and serum immune composition among mixed HIV-status mothers and their infants. Clin Nutr. 2016; 35: 871-879.
[31] Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny. Immunity Review. Immunity 46, March 21, 2017 ª 2017 Elsevier Inc. P/ 350-363.
[32] Reisinger KW, de Vaan L, Kramer BW, Wolfs TGAM, van Heurn LWE, Derikx JPM. Breast-feeding improves gut maturation compared with formula feeding in preterm babies. J Pediatr Gastroenterol Nutr. 2014; 59: 720-724.
[33] Rodríguez JM. The origin of human milk bacteria: is there a bacterial entero-mammary pathway during late pregnancy and lactation? Adv Nutr. 2014; 5: 779-784.
[34] Russell MW, Mestecky J, Strober W, Kelsall BL, Lambrecht BN, Cheroutre H. The mucosal immune system: Overview. In: Mestecky J, Strober W, Russell MW, Kelsall BL, Cheroutre H, Lambrecht BN, editors. Mucosal Immunology, 4. Amsterdam: Academic Press/Elsevier (2015). p. 3–8.
[35] Seelig L. L. J. and Beer A. E. Transepithelial migration of leucocytes in the mammary gland of lactating rats. Biol. Reprod., 1978, v. 17, № 9, p. 736-744.
[36] Shahani K. M., Kwan A. J., Friend B. A. Role and significance of enzymes in human milk. Am J Clin Nutr. 1980 Aug; 33 (8): 1861-8. doi: 10.1093/ajcn/33.8.1861.
[37] Shahid N. S., Steinhoff M. C., Roy E., Begum T., Thompson C. M., Siber G. R. Placental and breast transfer of antibodies after maternal immunization with polysaccharide meningococcal vaccine: A randomized, controlled evaluation. Vaccine. 2002; 20: 2404–2409.
[38] Sultanova, D. (2021). The influence of mother's extragenital pathology on the formation spleens of offspring in the early period postnatal ontogenesis. The Scientific Heritage, (81-2), 47-49.
[39] Trend S, de Jong E, Lloyd ML, et al. Leukocyte populations in human preterm and term breast milk identified by multicolour flow cytometry. PLoS One. 2015; 10: e0135580.
[40] Tuaillon E, Valea D, Becquart P, et al. Human milk-derived B cells: a highly activated switched memory cell population primed to secrete antibodies. J Immunol. 2009; 182: 7155-7162.
[41] Tukhtaev K. R. and other. Structural and functional relationships of immunocompetent cells of the mammary gland of lactating rats and small intestine of rat rats during breastfeeding // Morphology, No. 6, 124, 2003, S. 70-72.
[42] Turfkruyer M, Verhasselt V. Breast milk and its impact on maturation of the neonatal immune system. Curr Opin Infect Dis. 2015; 28: 199-206.
[43] Witkowska-Zimny, M., & Kaminska-El-Hassan, E. (2017). Cells of human breast milk. Cellular & molecular biology letters, 22 (1), 1-11.
[44] Yang, R. Q., Chen, M., Zhang, Q., Gao, Y. Y., Lou, K. L., Lin, T. T.,... & Zhang, G. J. (2022). Development and Preclinical Evaluation of a Near-Infrared Fluorescence Probe Based on Tailored Hepatitis B Core Particles for Imaging-Guided Surgery in Breast Cancer. International Journal of Nanomedicine, 17, 1343.
[45] Zufarov, K. A. and others. (2003). Quantitative and ultrastructural characteristics of immunocompetent cells in the mammary gland during pregnancy and lactation. Morfologiia (Saint Petersburg, Russia), 124 (4), 74-79.
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    Khasanov Bakhtiyor Burtkhanovich. (2022). Extragenital Pathology and Immunocompetent Cells Relations of Lactating Breast Gland and Offspring Jejunum. American Journal of Internal Medicine, 10(2), 28-33. https://doi.org/10.11648/j.ajim.20221002.12

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    ACS Style

    Khasanov Bakhtiyor Burtkhanovich. Extragenital Pathology and Immunocompetent Cells Relations of Lactating Breast Gland and Offspring Jejunum. Am. J. Intern. Med. 2022, 10(2), 28-33. doi: 10.11648/j.ajim.20221002.12

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    AMA Style

    Khasanov Bakhtiyor Burtkhanovich. Extragenital Pathology and Immunocompetent Cells Relations of Lactating Breast Gland and Offspring Jejunum. Am J Intern Med. 2022;10(2):28-33. doi: 10.11648/j.ajim.20221002.12

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  • @article{10.11648/j.ajim.20221002.12,
      author = {Khasanov Bakhtiyor Burtkhanovich},
      title = {Extragenital Pathology and Immunocompetent Cells Relations of Lactating Breast Gland and Offspring Jejunum},
      journal = {American Journal of Internal Medicine},
      volume = {10},
      number = {2},
      pages = {28-33},
      doi = {10.11648/j.ajim.20221002.12},
      url = {https://doi.org/10.11648/j.ajim.20221002.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20221002.12},
      abstract = {Researched the effect of chronic toxic maternal hepatitis on the cytometric features of immunocompetent cells (ICCls) of mammary gland tissues of the female and the jejunum of the offspring during breastfeeding. For morphological researches, pieces of the right inguinal mammary gland of female outbred rats with heliotrine hepatitis and the jejunum of the lean intestine of the offspring on days 1, 3, 7, 15 and 21 of lactation were used. Cytometric researches were carried out on semi-thin sections stained with methylene blue and pyronin G. It was established that in the last stages of pregnancy and in the first week after the onset of lactation, there is an increase in migration to the terminal secretory sections of the mammary gland of the ICCls, which indicates the participation of the mammary glands in the transfer of adoptive immunity to offspring and in maintaining the immune homeostasis of the small intestine, which decreases as the immune apparatus of the small intestine develops. A decrease in the number of ICCls migrating to the lactating mammary gland in case of mother's CTH negatively affects both immune adaptation and the structural and functional development and maturation of the immune apparatus of the jejunum of the offspring during breastfeeding.},
     year = {2022}
    }
    

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    T1  - Extragenital Pathology and Immunocompetent Cells Relations of Lactating Breast Gland and Offspring Jejunum
    AU  - Khasanov Bakhtiyor Burtkhanovich
    Y1  - 2022/04/26
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ajim.20221002.12
    DO  - 10.11648/j.ajim.20221002.12
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
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    EP  - 33
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20221002.12
    AB  - Researched the effect of chronic toxic maternal hepatitis on the cytometric features of immunocompetent cells (ICCls) of mammary gland tissues of the female and the jejunum of the offspring during breastfeeding. For morphological researches, pieces of the right inguinal mammary gland of female outbred rats with heliotrine hepatitis and the jejunum of the lean intestine of the offspring on days 1, 3, 7, 15 and 21 of lactation were used. Cytometric researches were carried out on semi-thin sections stained with methylene blue and pyronin G. It was established that in the last stages of pregnancy and in the first week after the onset of lactation, there is an increase in migration to the terminal secretory sections of the mammary gland of the ICCls, which indicates the participation of the mammary glands in the transfer of adoptive immunity to offspring and in maintaining the immune homeostasis of the small intestine, which decreases as the immune apparatus of the small intestine develops. A decrease in the number of ICCls migrating to the lactating mammary gland in case of mother's CTH negatively affects both immune adaptation and the structural and functional development and maturation of the immune apparatus of the jejunum of the offspring during breastfeeding.
    VL  - 10
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Author Information
  • Department of Histology, Cytology and Embryology, Bukhara State Medical Institute Named After Abu Ali ibn Sino (BSMI), Bukhara, Uzbekistan

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